Health Dysfunctions

Common pathophysiological changes and abnormal findings associated with musculoskeletal, metabolic, and multisystem health dysfunctions

Pathophysiological changes characterize alterations that lead to deranged functions of an organ or the entire human body. The abnormal findings due to the disease mean that an individual is not functioning in the desired way. The changes experienced in the body begin with continuous loading of the body with insufficient recovery time (EU-OSHA, 2020). Hence, the body grows less resistant to loading. It is caused by tumors, infection, or an injury on fascia, tendons, ligaments, cartilage, or joints that function as the connective tissues and voluntary muscles for the body.


            The musculoskeletal health dysfunction results from a mismatch between the external load and the human body capacity to resist physiological and biomedical strain (EU-OSHA, 2020). On the other hand, metabolic health dysfunctions are a combined condition leading to a risk increase of contracting type 2 diabetes, stroke, and heart disease. It is a result of stress from other illnesses such as cancer, trauma, or surgery. Multisystem health dysfunction is a potentially reversible physiologic derangement. It occurs when one is in a life-threatening physiologic insult in different two or more organs—for instance, an injury or disease such as an accident leading to the infection of an organ.

Symptoms associated with the findings and how they affect the patient function 

The symptoms result from the pathophysiological mechanisms in different body structures such as nerves, bones, joints, tendons, and muscles. The symptoms of musculoskeletal health dysfunction include tenderness, stiffness, less range of motion, muscle spams, warmth, edema, and numbness (Watson, 2020). They are mostly felt in organs such as the gallbladder, liver, and pancreases. They include hormonal regulation disruption leading to weight gain or loss. Multisystem health dysfunction symptoms include:

  • An increase or decrease in temperature.
  • A decrease in respiratory rate.
  • A decrease in heart rate.


EU-OSHA – European Agency for Safety and Health at Work. (2020). Pathophysiological mechanisms of musculoskeletal disorders. OSH WIKI.

Watson, S. (2020). Musculoskeletal Pain. Healthline.